General Information

  • ID:  hor005168
  • Uniprot ID:  P42992
  • Protein name:  Vasotocin-neurophysin VT
  • Gene name:  NA
  • Organism:  Sclerophrys regularis (Common African toad) (Bufo regularis)
  • Family:  Vasopressin/oxytocin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Sclerophrys (genus), Bufonidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005185 neurohypophyseal hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  CYIQNCPRGGKRSYPDTAVPQCIPCGP
  • Length:  27
  • Propeptide:  CYIQNCPRGGKRSYPDTAVPQCIPCGP
  • Signal peptide:  NA
  • Modification:  T9 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  antidiuretic activity
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  1-6
  • Structure ID:  AF-P42992-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P42992-F1.pdbhor005168_AF2.pdbhor005168_ESM.pdb

Physical Information

Mass: 338832 Formula: C124H195N37O37S4
Absent amino acids: EFHLMW Common amino acids: P
pI: 8.33 Basic residues: 3
Polar residues: 12 Hydrophobic residues: 4
Hydrophobicity: -56.3 Boman Index: -4445
Half-Life: 1.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 43.33
Instability Index: 4335.93 Extinction Coefficient cystines: 3230
Absorbance 280nm: 124.23

Literature

  • PubMed ID:  8097151
  • Title:  Vasotocin and hydrin 2 (vasotocinyl-Gly) in the African toad Bufo regularis: study under various environmental conditions.